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The first 2021/2022 detection of Eurasian strain (EA) highly pathogenic avian influenza (HPAI) H5N1 in North America occurred in December 2021 in Newfoundland and Labrador, Canada. Subsequently, HPAI EA H5 and EA H5N1 viruses have been confirmed in wild birds, backyard flocks, and commercial poultry facilities in both Canada and the United States. This HPAI distribution map will be updated weekly or as frequently as documented changes in distribution are available.