Climate change and invasive species threaten ecosystems across the Northwest and the world, creating significant challenges for managing our lands and waters. Although both are recognized as major threats, there are still many questions about how climate change and invasive species interact to create novel and complex challenges for our ecosystems. The Northwest Climate Adaptation Science Center (NW CASC), U.S. Fish & Wildlife Service and EcoAdapt have recently launched the Pacific Northwest Regional Invasive Species and Climate Change (PNW RISCC) Network to help natural resource managers and biologists incorporate climate change science into invasive species management. The network’s goal is to establish a community of practice that helps resource managers make climate-smart decisions around invasive species prevention, early detection, control, monitoring and future research activities.